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Sodium formate for injection

Products > Anti-neoplastic Drug Series > Sodium formate for injection

Sodium formate for injection

【Drug Name】

General name: Sodium formate for injection

English Name: Sodium Demethylcantharidate for Injection

Pinyin: Zhusheyong Qujiabanmaosuanna

 

【Ingredients】

The main component of this product is sodium sterigin.

Chemical name: 1,2-cis-3,6-oxy bridge-sodium hexahydrophthalic acid sodium salt.

Molecular formula: C8H8O5Na2

Molecular weight: 230.14

Accessories used: mannitol.

 

【Properties】 This product is a white or almost white lyophilized cake.

 

Indications

For liver cancer, esophageal cancer, stomach and cardia cancer, lung cancer, and leukopenia. It can also be used preoperatively for cancer or in combination with chemotherapy.

 

【Specification】 10mg

 

【Dosage】

1. Intravenous injection

Dissolve with appropriate amount of sterile water for injection and then dilute with 5% glucose injection and slowly inject intravenously. Once 10 ~ 30mg or as directed by your doctor. When intravenously instilled, dissolve with an appropriate amount of sterile water for injection and add slowly by adding 5% glucose injection 250-500ml.

2. Hepatic artery catheterization

Dissolve with appropriate amount of sterile water for injection, once for 10-30mg, twice a day. 1 month for a course of treatment, generally lasting 2 to 3 courses.

3. Intratumoral injection

Dissolve with appropriate amount of sterile water for injection, once for 10-30mg once a week, 4 times for 1 course of treatment, and continue for 4 courses.

 

[Adverse Reaction] If one injection exceeds 30mg, some patients may experience gastrointestinal symptoms such as nausea and vomiting.

 

[Contraindications] Allergy to this product is prohibited.

 

【Precautions】

1. When intravenously administered, care should be taken to avoid liquid leakage outside the vessel wall.

2. When injected intratumorally, the liquid is prevented from overflowing the tumor.

3. A small number of patients may use this product may increase body temperature, the use of high doses should pay attention to changes in body temperature. If the body temperature rises, it can be treated symptomatically.

4. Higher doses should be used with caution in patients with bleeding tendencies.

 

Pregnancy and lactation women drug use Pregnant women and lactating women should use drugs under the guidance of a doctor, as appropriate.

 

【Children's medication】 Children's dosage is reduced, usually 25% to 50% of the adult's dosage, can be applied under the guidance of a doctor.

 

[Geriatric Use] This experiment was not conducted and there is no reliable reference.

 

[drug interactions] is not yet clear.

 

Drug overdose

Overdose, some patients may have digestive tract reactions and heart, liver, kidney injury, discretionary treatment can be reduced.

 

Pharmacology and Toxicology

This product in vitro test has the function of destroying or inhibiting the morphology or proliferation of cell lines such as liver cancer, esophageal cancer, laryngeal cancer, lung cancer, and cervical cancer. In vivo test, it has a certain inhibitory effect on Ehrlich ascites carcinoma, sarcoma-180 and solid type of liver cancer. It can increase the respiratory control rate of mitochondria and lysosomal enzyme activity of ascites H22 liver cancer cells, and interfere with the division and resistance of cancer cells. Broken down to M phase and affecting its cycle speed. This product can destroy the cancer cell skeleton (microfilaments, microtubules), affect the ultrastructure of cancer cells, resulting in mitochondria, microvilli and plasma membrane damage. It can inhibit DNA synthesis of cancer cells, but it does not inhibit normal bone marrow cells and can increase leukocytes.

 

【Pharmacokinetics】

After intravenous administration of this product to the animals, it can be quickly distributed in various tissues, with higher drug concentrations in liver, kidney, lung, stomach, intestine, heart, salivary gland, thyroid, and cancer tissues; plasma concentration is about half an hour. After half of the treatment, the treatment was completely eliminated within 24 hours. The concentration of the drug in the liver reached a peak at 1 hour, and it decreased by half at 6 hours and completely eliminated at 24 hours. The drug was excreted mainly through the urinary system. After intravenous injection, the concentration of the drug in urine peaked at 0.5 to 1 hour. 24 Most of the hours are discharged from the urine.

 

[Storage] Shade, closed, kept in a cool dry place.

 

【Packing】 Glass bottle, 1 / box.

 

【Valid period】 24 months.

 

[Executive standard] YBH14442006

 

【Approval number】 National drug license H20061092


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